Our arsenal to treat bacterial infections is rapidly diminishing as an increasing number of human bacterial pathogens are resistant to existing antimicrobials / antibiotics. To understand the genetic and biochemical basis of resistance and to develop new antimicrobials, I started a scientific program in 2012 titled 'Taskforce to study Resistance Emergence & Antimicrobial development Technology' (TREAT). This program comprises of collaborative laboratories around the world with varying expertise but only one goal, that is, to develop new antibiotics and to understand how bugs resist them.
Here, I will share publications relevant to antimicrobial resistance and new antimicrobials. I will also post results of our (TREAT) effort.

Thursday, February 19, 2015

Friday, December 5, 2014

Antimicrobial Development Effort by Pharma

Here is an excellent 2007 report on effort by pharma to develop new antimicrobials in response to 'bad bugs' that are resistant to many existing drugs. Click here.

IDSA declares epidemic of 'Bad Bugs No Drugs'

In 2008, a group of senior IDSA (Infectious Diseases Society of America) members published a report describing epidemics of "Bad Bugs" or bacterial pathogens that are increasingly becoming difficult to treat due to their developing resistance to existing drugs. Click here to access this paper.